Inhibition of Snail1-DNA-PKcs protein-protein interface sensitizes cancer cells and inhibits tumor metastasis
GY Kang, BJ Pyun, HR Seo, YB Jin, HJ Lee… - Journal of Biological …, 2013 - jbc.org
Our previous study suggested that the DNA-dependent protein kinase catalytic subunit (DNA-
PKcs) interacts with Snail1, which affects genomic instability, sensitivity to DNA-damaging
agents, and migration of tumor cells by reciprocal regulation between DNA-PKcs and Snail1.
Here, we further investigate that a peptide containing 7-amino acid sequences (amino acids
15–21) of Snail1 (KPNYSEL, SP) inhibits the endogenous interaction between DNA-PKcs
and Snail1 through primary interaction with DNA-PKcs. SP restored the inhibited DNA-PKcs …
PKcs) interacts with Snail1, which affects genomic instability, sensitivity to DNA-damaging
agents, and migration of tumor cells by reciprocal regulation between DNA-PKcs and Snail1.
Here, we further investigate that a peptide containing 7-amino acid sequences (amino acids
15–21) of Snail1 (KPNYSEL, SP) inhibits the endogenous interaction between DNA-PKcs
and Snail1 through primary interaction with DNA-PKcs. SP restored the inhibited DNA-PKcs …
