Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer
SH Huang, B Perez-Ordonez, I Weinreb, A Hope… - Oral oncology, 2013 - Elsevier
Oral oncology, 2013•Elsevier
OBJECTIVES: To describe the natural course of distant metastases (DMs) following
radiotherapy (RT) or chemoradiotherapy (CRT) in HPV (+) oropharyngeal carcinoma (OPC).
METHODS: OPC treated with RT/CRT from 1/1/2000 to 5/31/2010 were reviewed. The
natural course of DM were compared between HPV (+) and HPV (−) cohorts. RESULTS:
Median follow-up was 3.9 years. The DM rate were similar (11% vs. 15% at 3-years, p= 0.25)
between the HPV (+)(n= 457) vs. the HPV (−)(n= 167) cases. While almost all (24/25) HPV …
radiotherapy (RT) or chemoradiotherapy (CRT) in HPV (+) oropharyngeal carcinoma (OPC).
METHODS: OPC treated with RT/CRT from 1/1/2000 to 5/31/2010 were reviewed. The
natural course of DM were compared between HPV (+) and HPV (−) cohorts. RESULTS:
Median follow-up was 3.9 years. The DM rate were similar (11% vs. 15% at 3-years, p= 0.25)
between the HPV (+)(n= 457) vs. the HPV (−)(n= 167) cases. While almost all (24/25) HPV …
OBJECTIVES
To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC).
METHODS
OPC treated with RT/CRT from 1/1/2000 to 5/31/2010 were reviewed. The natural course of DM were compared between HPV(+) and HPV(−) cohorts.
RESULTS
Median follow-up was 3.9years. The DM rate were similar (11% vs. 15% at 3-years, p=0.25) between the HPV(+) (n=457) vs. the HPV(−) (n=167) cases. While almost all (24/25) HPV(−) DM occurred within 2-years following RT (1 was at 2.1years), 7/54 (13%) of HPV(+) DM were detected beyond 3years (up to 5.3years). Disseminating to >2 organs occurred in 18 (33%) HPV(+) vs. none in HPV(−). Post-DM survival rates were 11% vs. 4% at 2-years (p=0.02) for the HPV(+) vs. HPV(−) cases respectively. 5/6 HPV(+) with lung oligo-metastasis were still alive with stable disease beyond 2-years after salvage procedures for DM (chemotherapy: 3; surgical resection: 2; radiotherapy: 1).
CONCLUSIONS
Although DM rates are similar, the natural course of HPV(+) DM differs from that of HPV(−) patients: it may occur after a longer interval, often with a “disseminating” phenotype, and a small number may have prolonged survival after salvage for DM.
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