Plasmalogen modulation attenuates atherosclerosis in ApoE-and ApoE/GPx1-deficient mice
Background and aim We previously reported a negative association of circulating
plasmalogens (phospholipids with proposed atheroprotective properties) with coronary
artery disease. Plasmalogen modulation was previously demonstrated in animals but its
effect on atherosclerosis was unknown. We assessed the effect of plasmalogen enrichment
on atherosclerosis of murine models with differing levels of oxidative stress. Methods and
results Six-week old ApoE-and ApoE/glutathione peroxidase-1 (GPx1)-deficient mice were …
plasmalogens (phospholipids with proposed atheroprotective properties) with coronary
artery disease. Plasmalogen modulation was previously demonstrated in animals but its
effect on atherosclerosis was unknown. We assessed the effect of plasmalogen enrichment
on atherosclerosis of murine models with differing levels of oxidative stress. Methods and
results Six-week old ApoE-and ApoE/glutathione peroxidase-1 (GPx1)-deficient mice were …
