Hypoxia Studies with Pimonidazole in vivo
KY Aguilera, RA Brekken - Bio-protocol, 2014 - bio-protocol.org
Therapy-induced hypoxia drives changes in the tumor microenvironment that contribute to
the poor response to therapy. Hypoxia is capable of driving the expression and/or activation
of specific signaling cascades (eg, c-Met, Axl, CTGF), the recruitment of tumor promoting
immune cells, and the induction of cell survival pathways including autophagy (Phan et al.,
2013; Hu et al., 2012; Ye et al., 2010). We have recently shown that anti-VEGF therapy-
induced hypoxia can result in changes in the extracellular matrix that contribute to the …
the poor response to therapy. Hypoxia is capable of driving the expression and/or activation
of specific signaling cascades (eg, c-Met, Axl, CTGF), the recruitment of tumor promoting
immune cells, and the induction of cell survival pathways including autophagy (Phan et al.,
2013; Hu et al., 2012; Ye et al., 2010). We have recently shown that anti-VEGF therapy-
induced hypoxia can result in changes in the extracellular matrix that contribute to the …
