Regulatory T cells and T cell depletion: role of immunosuppressive drugs

M Noris, F Casiraghi, M Todeschini… - Journal of the …, 2007 - journals.lww.com
Allogeneic immune responses are modulated by a subset of host T cells with regulatory
function (Treg) contained within the CD4+ CD25 high subset. Evidence exists that Treg
expand after peritransplantation lymphopenia, inhibit graft rejection, and induce and
maintain tolerance. Little, however, is known about the role of Treg in the clinical setting. IL-2
and activation by T cell receptor engagement are instrumental to generate and maintain
Treg, but the influence of immunosuppressants on Treg homeostasis in humans in vivo has …