Interleukin-22 and cyclosporine in aggressive cutaneous squamous cell carcinoma
AL Santana, D Felsen, JA Carucci - Dermatologic clinics, 2017 - derm.theclinics.com
Cutaneous squamous cell carcinoma (SCC) is the second most common human
malignancy, with more than 700,000 cases expected in 2016. 1–4 Although typically curable
by excision with clear margins, SCC can behave aggressively and metastasize to local
lymph nodes despite treatment. 5–7 Cutaneous SCC is characterized by the malignant
proliferation of keratinocytes that typically occurs on sun-damaged skin and tends to develop
within areas of noninvasive actinic keratosis (AK). Progression from AK to SCC is thought to …
malignancy, with more than 700,000 cases expected in 2016. 1–4 Although typically curable
by excision with clear margins, SCC can behave aggressively and metastasize to local
lymph nodes despite treatment. 5–7 Cutaneous SCC is characterized by the malignant
proliferation of keratinocytes that typically occurs on sun-damaged skin and tends to develop
within areas of noninvasive actinic keratosis (AK). Progression from AK to SCC is thought to …