Cyclosporine A suppresses keratinocyte cell death through MPTP inhibition in a model for skin cancer in organ transplant recipients
Transplant recipients have an elevated risk of skin cancer, with a 65-to 250-fold increase in
squamous cell carcinoma. Usage of the immunosuppressant cyclosporine A (CsA) is
associated with the development of skin cancer. We hypothesized that the increased
incidence of skin cancer was due to the action of CsA within keratinocyte mitochondria
where it can inhibit mitochondrial permeability transition pore (MPTP) opening. Normally,
MPTP opening is induced by oxidative stress such as that caused by UV light and leads to …
squamous cell carcinoma. Usage of the immunosuppressant cyclosporine A (CsA) is
associated with the development of skin cancer. We hypothesized that the increased
incidence of skin cancer was due to the action of CsA within keratinocyte mitochondria
where it can inhibit mitochondrial permeability transition pore (MPTP) opening. Normally,
MPTP opening is induced by oxidative stress such as that caused by UV light and leads to …