Rapid activation and hepatic recruitment of innate-like regulatory B cells after invariant NKT cell stimulation in mice
W Almishri, J Deans, MG Swain - Journal of hepatology, 2015 - Elsevier
Background & Aims Invariant natural killer T (iNKT) cells are present within the liver and
have been implicated in the development of many liver diseases. Upon activation by
glycolipid ligands (including α-galactosylceramide; αGalCer), hepatic iNKT cells produce
numerous cytokines and recruit both pro-inflammatory and regulatory immune cells.
However, the involvement of B cells in this process is poorly defined. Methods Wild-type
(male, C57BL/6), B cell deficient, or B cell depleted mice were injected with αGalCer or …
have been implicated in the development of many liver diseases. Upon activation by
glycolipid ligands (including α-galactosylceramide; αGalCer), hepatic iNKT cells produce
numerous cytokines and recruit both pro-inflammatory and regulatory immune cells.
However, the involvement of B cells in this process is poorly defined. Methods Wild-type
(male, C57BL/6), B cell deficient, or B cell depleted mice were injected with αGalCer or …