Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells
M Goto, M Murakawa, K Kadoshima-Yamaoka… - Cellular …, 2009 - Elsevier
A possible involvement of phosphodiesterase 7A (PDE7A) in proliferation and function of
NKT cells was examined using ASB16165, a selective inhibitor for PDE7A. Stimulation of
isolated murine NKT cells with anti-CD3 antibody plus IL-2 induced not only cell proliferation
but production of cytokines including IFN-γ, TNF-α, IL-17 and IL-22. ASB16165 significantly
inhibited the CD3/IL-2-stimulated cell proliferation and production of all the cytokines
examined. Forskolin (an activator of adenylyl cyclase) and dibutyryl cAMP also exerted …
NKT cells was examined using ASB16165, a selective inhibitor for PDE7A. Stimulation of
isolated murine NKT cells with anti-CD3 antibody plus IL-2 induced not only cell proliferation
but production of cytokines including IFN-γ, TNF-α, IL-17 and IL-22. ASB16165 significantly
inhibited the CD3/IL-2-stimulated cell proliferation and production of all the cytokines
examined. Forskolin (an activator of adenylyl cyclase) and dibutyryl cAMP also exerted …