[HTML][HTML] NKT-cell subsets: promoters and protectors in inflammatory liver disease
V Kumar - Journal of hepatology, 2013 - Elsevier
Natural killer T cells (NKT) are innate-like cells which are abundant in liver sinusoids and
express the cell surface receptors of NK cells (eg, NK1. 1 (mouse) or CD161+/CD56+
(human)) as well as an antigen receptor (TCR) characteristic of conventional T cells. NKT
cells recognize lipid antigens in the context of CD1d, a non-polymorphic MHC class I-like
molecule. Activation of NKT cells has a profound influence on the immune response against
tumors and infectious organisms and in autoimmune diseases. NKT cells can be …
express the cell surface receptors of NK cells (eg, NK1. 1 (mouse) or CD161+/CD56+
(human)) as well as an antigen receptor (TCR) characteristic of conventional T cells. NKT
cells recognize lipid antigens in the context of CD1d, a non-polymorphic MHC class I-like
molecule. Activation of NKT cells has a profound influence on the immune response against
tumors and infectious organisms and in autoimmune diseases. NKT cells can be …