T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription
T Usui, JC Preiss, Y Kanno, ZJ Yao, JH Bream… - Journal of Experimental …, 2006 - rupress.org
Journal of Experimental Medicine, 2006•rupress.org
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on
IFNG gene acetylation and transcriptio Page 1 The Journal of Experimental Medicine
ARTICLE Vol. 203, No. 3, March 20, 2006 755–766 www.jem.org/cgi/doi/10.1084/jem.20052165
755 Over the past several years, the molecular mechanisms governing Th1 differentiation
have led to the identification of two major Th1related signaling pathways, one involving IL12/STAT4
(1–11) and the other involving IFN-γ/STAT1/T-bet (8–11). Of these, the latter or T-bet …
IFNG gene acetylation and transcriptio Page 1 The Journal of Experimental Medicine
ARTICLE Vol. 203, No. 3, March 20, 2006 755–766 www.jem.org/cgi/doi/10.1084/jem.20052165
755 Over the past several years, the molecular mechanisms governing Th1 differentiation
have led to the identification of two major Th1related signaling pathways, one involving IL12/STAT4
(1–11) and the other involving IFN-γ/STAT1/T-bet (8–11). Of these, the latter or T-bet …
RESULTS Elevated IL-4 and GATA-3 in committed Th2 cells of T-bet−/− mice
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