Canonical and non-canonical adenosinergic pathways
E Ferretti, AL Horenstein, C Canzonetta, F Costa… - Immunology letters, 2019 - Elsevier
Adenosine (ADO) is an immunosuppressive molecule with multiple functions in different
human organs. ADO is released through the concerted action of surface molecules
endowed with enzymatic functions, that belong to two different adenosinergic pathways. The
canonical pathway is started by CD39, that converts ATP to AMP. On the other hand, the non-
canonical pathway metabolizes NAD+ to ADPR, through the action of CD38. The latter
byproduct is then converted to AMP by CD203a/PC-1. Both pathways converge to CD73 …
human organs. ADO is released through the concerted action of surface molecules
endowed with enzymatic functions, that belong to two different adenosinergic pathways. The
canonical pathway is started by CD39, that converts ATP to AMP. On the other hand, the non-
canonical pathway metabolizes NAD+ to ADPR, through the action of CD38. The latter
byproduct is then converted to AMP by CD203a/PC-1. Both pathways converge to CD73 …
