[HTML][HTML] Lipocalin-2 (24p3/neutrophil gelatinase-associated lipocalin (NGAL)) receptor is expressed in distal nephron and mediates protein endocytosis
C Langelueddecke, E Roussa, RA Fenton… - Journal of Biological …, 2012 - ASBMB
In the kidney, bulk reabsorption of filtered proteins occurs in the proximal tubule via receptor-
mediated endocytosis (RME) through the multiligand receptor complex megalin-cubilin.
Other mechanisms and nephron sites for RME of proteins are unclear. Recently, the
secreted protein 24p3 (lipocalin-2, neutrophil gelatinase-associated lipocalin (NGAL)),
which is expressed in the distal nephron, has been identified as a sensitive biomarker of
kidney damage. A high-affinity receptor for 24p3 (24p3R) that is involved in endocytotic iron …
mediated endocytosis (RME) through the multiligand receptor complex megalin-cubilin.
Other mechanisms and nephron sites for RME of proteins are unclear. Recently, the
secreted protein 24p3 (lipocalin-2, neutrophil gelatinase-associated lipocalin (NGAL)),
which is expressed in the distal nephron, has been identified as a sensitive biomarker of
kidney damage. A high-affinity receptor for 24p3 (24p3R) that is involved in endocytotic iron …