Aldosterone in progressive renal disease

TH Hostetter, ME Rosenberg… - Seminars in …, 2001 - seminarsinnephrology.org
Blockade of the renin-angiotensin-aldosterone system has proven effective in retarding
progression of renal disease in the remnant kidney model, as well as other experimental
diseases, and, most importantly, in a range of progressive human renal diseases. Attention
has focused on the role of angiotensin II (Ang II) in propagating progression both by its
hemodynamic and nonhemodynamic actions. Recent evidence, predominately In the
remnant kidney model, indicates that the drugs used to block this hormone system …