The role of aldosterone has expanded from the hormone's genomic effects that involve renal
sodium transport to nongenomic effects that are independent of the effect of aldosterone on
sodium transport. The nongenomic effects of aldosterone to increase fibrosis, collagen
deposition, inflammation, and remodeling of the heart and blood vessels, however, are
markedly increased in the presence of high sodium intake. The genomic effect of
aldosterone increases renal sodium transport, but the administration of large doses of …