Background Generalized pustular psoriasis (GPP) is a rare, debilitating, and often life-
threatening inflammatory disease characterized by episodic infiltration of neutrophils into the
skin, pustule development, and systemic inflammation, which can manifest in the presence
or absence of chronic plaque psoriasis (PV). Current treatments are unsatisfactory and
warrant a better understanding of GPP pathogenesis. Objective We sought to understand
better the disease mechanism of GPP to allow improved targeted therapies. Methods We …