Molecular signatures associated with clinical outcome in patients with high-risk head-and-neck squamous cell carcinoma treated by surgery and radiation
U Giri, CL Ashorn, L Ramdas, DN Stivers… - International Journal of …, 2006 - Elsevier
Purpose: The local-regional control rate for advanced head-and-neck squamous cell
carcinoma (HNSCC) remains poor and is unpredictable for a given individual. This study
examined whether gene expression patterns developed from tumors from surgicopathologic,
criteria-defined, high-risk HNSCC patients could be correlated with clinical outcomes,
namely, metastasis or nonrecurrent disease. Methods and Materials: Fifteen primary tumors
from patients treated with a consistent protocol of surgery followed by radiotherapy were …
carcinoma (HNSCC) remains poor and is unpredictable for a given individual. This study
examined whether gene expression patterns developed from tumors from surgicopathologic,
criteria-defined, high-risk HNSCC patients could be correlated with clinical outcomes,
namely, metastasis or nonrecurrent disease. Methods and Materials: Fifteen primary tumors
from patients treated with a consistent protocol of surgery followed by radiotherapy were …
