HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer
P Lassen, JG Eriksen, S Hamilton-Dutoit… - Radiotherapy and …, 2010 - Elsevier
BACKGROUND: HPV/p16-positive head and neck cancers (HNSCC) show superior
response to radiotherapy, compared with virus-negative tumours. Tumour hypoxia induces
radioresistance and the randomised DAHANCA 5 trial found that the hypoxic cell
radiosensitiser nimorazole significantly improved the outcome in HNSCC. Using p16-status
as a retrospective stratification parameter, we aimed to assess the influence of p16-
expression on the response to nimorazole in HNSCC. MATERIALS AND METHODS: Pre …
response to radiotherapy, compared with virus-negative tumours. Tumour hypoxia induces
radioresistance and the randomised DAHANCA 5 trial found that the hypoxic cell
radiosensitiser nimorazole significantly improved the outcome in HNSCC. Using p16-status
as a retrospective stratification parameter, we aimed to assess the influence of p16-
expression on the response to nimorazole in HNSCC. MATERIALS AND METHODS: Pre …
