[HTML][HTML] Effects of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes
Y Nakagawa, Y Negishi, M Shimizu, M Takahashi… - Immunology letters, 2015 - Elsevier
The major effector cells for cellular adaptive immunity are CD8+ cytotoxic T lymphocytes
(CTLs), which can recognize and kill virus-infected cells and tumor cells. Although CTLs
exhibit strong cytolytic activity against target cells in vitro, a number of studies have
demonstrated that their function is often impaired within tumors. Nevertheless, CTLs can
regain their cytotoxic ability after escaping from the tumor environment, suggesting that the
milieu created by tumors may affect the function of CTLs. As for the tumor environment, the …
(CTLs), which can recognize and kill virus-infected cells and tumor cells. Although CTLs
exhibit strong cytolytic activity against target cells in vitro, a number of studies have
demonstrated that their function is often impaired within tumors. Nevertheless, CTLs can
regain their cytotoxic ability after escaping from the tumor environment, suggesting that the
milieu created by tumors may affect the function of CTLs. As for the tumor environment, the …