ROCK inhibition with Y27632 promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord
Z Yu, M Liu, P Fu, M Xie, W Wang, X Luo - Neurochemistry international, 2012 - Elsevier
Rho-associated Kinase (ROCK) has been identified as an important regulator of proliferation
and cell cycle progression in a number of cell types. Although its effects on astrocyte
proliferation have not been well characterized, ROCK has been reported to play important
roles in gap junction formation, morphology, and migration of astrocytes. In the present
study, our aim was to investigate the effect of ROCK inhibition by [(+)-(R)-trans-4-(1-
aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride](Y27632) on …
and cell cycle progression in a number of cell types. Although its effects on astrocyte
proliferation have not been well characterized, ROCK has been reported to play important
roles in gap junction formation, morphology, and migration of astrocytes. In the present
study, our aim was to investigate the effect of ROCK inhibition by [(+)-(R)-trans-4-(1-
aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride](Y27632) on …