IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis
M Vasakova, M Sterclova, R Matej, T Olejar… - Human Immunology, 2013 - Elsevier
Aims We studied the influence of IL-4 gene polymorphisms on the IPF phenotype, ie, extent
of radiological changes (HRCT interstitial (IS) and alveolar (AS) score) and histopathological
markers from lung biopsies. Patients and methods 46 IPF patients underwent genotyping, 43
of them had HRCT and 14 patients had a surgical lung biopsy. The HRCT scans were
evaluated for AS and IS. The histopathological evaluation comprised myofibroblast foci (MF),
intensity of inflammation and fibrosis (Ashcroft score) and numbers of eosinophils and …
of radiological changes (HRCT interstitial (IS) and alveolar (AS) score) and histopathological
markers from lung biopsies. Patients and methods 46 IPF patients underwent genotyping, 43
of them had HRCT and 14 patients had a surgical lung biopsy. The HRCT scans were
evaluated for AS and IS. The histopathological evaluation comprised myofibroblast foci (MF),
intensity of inflammation and fibrosis (Ashcroft score) and numbers of eosinophils and …