Liddle's syndrome (or pseudoaldosteronism) is an autosomal dominant form of salt-sensitive
hypertension, due to abnormal sodium transport by the renal tubule. To study the
pathophysiology of salt sensitivity, a mouse model for Liddle's syndrome has been
generated by Cre/loxP-mediated recombination. Under normal salt diet, mice heterozygous
(L/+) and homozygous (L/L) for Liddle mutation (L) develop normally during the first 3 mo of
life. In these mice, BP is not different from wild type despite evidence for increased sodium …