Nicotinamide mononucleotide, an NAD+ precursor, rescues age-associated susceptibility to AKI in a sirtuin 1–dependent manner
Y Guan, SR Wang, XZ Huang, Q Xie… - Journal of the …, 2017 - journals.lww.com
The rapid growth of an aging population creates challenges regarding age-related diseases,
including AKI, for which both the prevalence and death rate increase with age. The
molecular mechanism by which the aged kidney becomes more susceptible to acute injury
has not been completely elucidated. In this study, we found that, compared with the kidneys
of 3-month-old mice, the kidneys of 20-month-old mice expressed reduced levels of the
renal protective molecule sirtuin 1 (SIRT1) and its cofactor NAD+. Supplementation with …
including AKI, for which both the prevalence and death rate increase with age. The
molecular mechanism by which the aged kidney becomes more susceptible to acute injury
has not been completely elucidated. In this study, we found that, compared with the kidneys
of 3-month-old mice, the kidneys of 20-month-old mice expressed reduced levels of the
renal protective molecule sirtuin 1 (SIRT1) and its cofactor NAD+. Supplementation with …
