Urine ammonium predicts clinical outcomes in hypertensive kidney disease

KL Raphael, DJ Carroll, J Murray… - Journal of the …, 2017 - journals.lww.com
Metabolic acidosis is associated with poor outcomes in CKD. Because impaired renal
ammonium excretion is important in the pathogenesis of acidosis, urine ammonium
excretion might be a better and perhaps earlier acid–base indicator of risk than serum
bicarbonate, particularly in patients without acidosis. We evaluated the association between
baseline ammonium excretion and clinical outcomes in African American Study of Kidney
Disease and Hypertension participants (n= 1044). Median daily ammonium excretion was …