Impaired glucose and insulin homeostasis in moderate-severe CKD
IH de Boer, L Zelnick, M Afkarian, E Ayers… - Journal of the …, 2016 - journals.lww.com
Kidney disease leads to clinically relevant disturbances in glucose and insulin homeostasis,
but the pathophysiology in moderate-severe CKD remains incompletely defined. In a cross-
sectional study of 59 participants with nondiabetic CKD (mean eGFR= 37.6 ml/min per 1.73
m 2) and 39 healthy control subjects, we quantified insulin sensitivity, clearance, and
secretion and glucose tolerance using hyperinsulinemic-euglycemic clamp and intravenous
and oral glucose tolerance tests. Participants with CKD had lower insulin sensitivity than …
but the pathophysiology in moderate-severe CKD remains incompletely defined. In a cross-
sectional study of 59 participants with nondiabetic CKD (mean eGFR= 37.6 ml/min per 1.73
m 2) and 39 healthy control subjects, we quantified insulin sensitivity, clearance, and
secretion and glucose tolerance using hyperinsulinemic-euglycemic clamp and intravenous
and oral glucose tolerance tests. Participants with CKD had lower insulin sensitivity than …