Leucine-rich repeat containing 8A (LRRC8A)–dependent volume-regulated anion channel activity is dispensable for T-cell development and function
Background Leucine-rich repeat containing 8A (LRRC8A) is an ubiquitously expressed
transmembrane protein with 17 leucine-rich repeats (LRRs) at its C-terminal end and is an
essential component of the volume-regulated anion channel (VRAC), which controls cellular
volume. A heterozygous mutation in LRRC8A that truncates the 2 terminal LRRs was
reported in a patient with agammaglobulinemia and absent B cells and was demonstrated to
exert a dominant negative effect on T-and B-cell development in mice. Lrrc8a−/− mice have …
transmembrane protein with 17 leucine-rich repeats (LRRs) at its C-terminal end and is an
essential component of the volume-regulated anion channel (VRAC), which controls cellular
volume. A heterozygous mutation in LRRC8A that truncates the 2 terminal LRRs was
reported in a patient with agammaglobulinemia and absent B cells and was demonstrated to
exert a dominant negative effect on T-and B-cell development in mice. Lrrc8a−/− mice have …