Expanding roles of ABCG1 and sterol transport
EJ Tarling - Current opinion in lipidology, 2013 - journals.lww.com
EJ Tarling
Current opinion in lipidology, 2013•journals.lww.comABCG1 plays a crucial role in maintaining intracellular sterol and lipid homeostasis. Loss of
this transporter has significant, cell-type-specific consequences ranging from effects on
cellular proliferation, to surfactant production and/or insulin secretion. Elucidation of the
mechanisms by which ABCG1 affects intracellular sterol flux/movement should provide
important information that may link ABCG1 to diseases of dysregulated tissue lipid
homeostasis.
this transporter has significant, cell-type-specific consequences ranging from effects on
cellular proliferation, to surfactant production and/or insulin secretion. Elucidation of the
mechanisms by which ABCG1 affects intracellular sterol flux/movement should provide
important information that may link ABCG1 to diseases of dysregulated tissue lipid
homeostasis.
Summary
ABCG1 plays a crucial role in maintaining intracellular sterol and lipid homeostasis. Loss of this transporter has significant, cell-type-specific consequences ranging from effects on cellular proliferation, to surfactant production and/or insulin secretion. Elucidation of the mechanisms by which ABCG1 affects intracellular sterol flux/movement should provide important information that may link ABCG1 to diseases of dysregulated tissue lipid homeostasis.
Lippincott Williams & Wilkins