AIBP reduces atherosclerosis by promoting reverse cholesterol transport and ameliorating inflammation in apoE−/− mice
M Zhang, GJ Zhao, F Yao, XD Xia, D Gong, ZW Zhao… - Atherosclerosis, 2018 - Elsevier
Background and aims ApoA-1 binding protein (AIBP) is a secreted protein that interacts with
apoA-I and accelerates cholesterol efflux from cells. We have recently reported that AIBP
promotes apoA-1 binding to ABCA1 in the macrophage cell membrane, partially through
115–123 amino acids. However, the effects of AIBP on the development of atherosclerosis in
vivo remain unknown. Methods ApoE−/− mice with established atherosclerotic plaques were
infected with rAAV-AIBP or rAAV-AIBP (Δ115-123), respectively. Results AIBP-treated mice …
apoA-I and accelerates cholesterol efflux from cells. We have recently reported that AIBP
promotes apoA-1 binding to ABCA1 in the macrophage cell membrane, partially through
115–123 amino acids. However, the effects of AIBP on the development of atherosclerosis in
vivo remain unknown. Methods ApoE−/− mice with established atherosclerotic plaques were
infected with rAAV-AIBP or rAAV-AIBP (Δ115-123), respectively. Results AIBP-treated mice …