Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation
M Zhang, L Li, W Xie, JF Wu, F Yao, YL Tan, XD Xia… - Atherosclerosis, 2016 - Elsevier
Rationale Previous studies have shown that apolipoprotein-1 (apoA-1) binding protein
(AIBP) is highly associated with the regulation of apoA-1 metabolism, suggesting its role in
the treatment of atherosclerosis. However, how AIBP regulates foam cell formation remains
largely unexplored. Objective To investigate the mechanisms underlying AIBP inhibition of
foam cell formation from macrophages. Methods and results THP-1-derived macrophages
were incubated without or with apoA-1 and AIBP, followed by assessing the formation of …
(AIBP) is highly associated with the regulation of apoA-1 metabolism, suggesting its role in
the treatment of atherosclerosis. However, how AIBP regulates foam cell formation remains
largely unexplored. Objective To investigate the mechanisms underlying AIBP inhibition of
foam cell formation from macrophages. Methods and results THP-1-derived macrophages
were incubated without or with apoA-1 and AIBP, followed by assessing the formation of …