[HTML][HTML] Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress
H Tanjore, DS Cheng, AL Degryse, DF Zoz… - Journal of biological …, 2011 - ASBMB
Expression of mutant surfactant protein C (SFTPC) results in endoplasmic reticulum (ER)
stress in type II alveolar epithelial cells (AECs). AECs have been implicated as a source of
lung fibroblasts via epithelial-to-mesenchymal transition (EMT); therefore, we investigated
whether ER stress contributes to EMT as a possible mechanism for fibrotic remodeling. ER
stress was induced by tunicamyin administration or stable expression of mutant (L188Q)
SFTPC in type II AEC lines. Both tunicamycin treatment and mutant SFTPC expression …
stress in type II alveolar epithelial cells (AECs). AECs have been implicated as a source of
lung fibroblasts via epithelial-to-mesenchymal transition (EMT); therefore, we investigated
whether ER stress contributes to EMT as a possible mechanism for fibrotic remodeling. ER
stress was induced by tunicamyin administration or stable expression of mutant (L188Q)
SFTPC in type II AEC lines. Both tunicamycin treatment and mutant SFTPC expression …