[PDF][PDF] IRE1, a double-edged sword in pre-miRNA slicing and cell death

J Hassler, SS Cao, RJ Kaufman - Developmental cell, 2012 - cell.com
J Hassler, SS Cao, RJ Kaufman
Developmental cell, 2012cell.com
IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles
in many biological processes and cell fate decisions. Reporting in Science, Upton et
al.(2012) broadened our understanding of IRE1α as a cell-death executioner, showing that
upon ER stress, IRE1α degrades microRNAs to promote translation of caspase-2.
IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote translation of caspase-2.
cell.com