[HTML][HTML] Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease
G Basurto-Islas, I Grundke-Iqbal, YC Tung, F Liu… - Journal of Biological …, 2013 - ASBMB
Neurofibrillary pathology of abnormally hyperphosphorylated Tau is a key lesion of
Alzheimer disease and other tauopathies, and its density in the brain directly correlates with
dementia. The phosphorylation of Tau is regulated by protein phosphatase 2A, which in turn
is regulated by inhibitor 2, I 2 PP2A. In acidic conditions such as generated by brain
ischemia and hypoxia, especially in association with hyperglycemia as in diabetes, I 2 PP2A
is cleaved by asparaginyl endopeptidase at Asn-175 into the N-terminal fragment (I 2NTF) …
Alzheimer disease and other tauopathies, and its density in the brain directly correlates with
dementia. The phosphorylation of Tau is regulated by protein phosphatase 2A, which in turn
is regulated by inhibitor 2, I 2 PP2A. In acidic conditions such as generated by brain
ischemia and hypoxia, especially in association with hyperglycemia as in diabetes, I 2 PP2A
is cleaved by asparaginyl endopeptidase at Asn-175 into the N-terminal fragment (I 2NTF) …