[HTML][HTML] Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery

S Ghosh, JR Paez-Cortez, K Boppidi… - Journal of Biological …, 2011 - ASBMB
Notch3 signaling is fundamental for arterial specification of systemic vascular smooth
muscle cells (VSMCs). However, the developmental role and signaling properties of the
Notch3 receptor in the mouse pulmonary artery remain unknown. Here, we demonstrate that
Notch3 is expressed selectively in pulmonary artery VSMCs, is activated from late fetal to
early postnatal life, and is required to maintain the morphological characteristics and smooth
muscle gene expression profile of the pulmonary artery after birth. Using a conditional knock …