HHIP, HDAC4, NCR3 and RARB polymorphisms affect fetal, childhood and adult lung function
European Respiratory Journal, 2013•Eur Respiratory Soc
Impaired lung function, and consequent respiratory morbidity including asthma and chronic
obstructive pulmonary disease, may have their origins in early life [1–3]. Genome-wide
analysis studies (GWAS) have identified a number of single-nucleotide polymorphisms
(SNPs) in those of European ancestry that affect adult lung function, as measured by forced
expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) ratio. 23 of these SNPs
have directionally consistent effects on both FEV1 and FEV1/FVC in children and adults [4].
obstructive pulmonary disease, may have their origins in early life [1–3]. Genome-wide
analysis studies (GWAS) have identified a number of single-nucleotide polymorphisms
(SNPs) in those of European ancestry that affect adult lung function, as measured by forced
expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) ratio. 23 of these SNPs
have directionally consistent effects on both FEV1 and FEV1/FVC in children and adults [4].
Impaired lung function, and consequent respiratory morbidity including asthma and chronic obstructive pulmonary disease, may have their origins in early life [1–3]. Genome-wide analysis studies (GWAS) have identified a number of single-nucleotide polymorphisms (SNPs) in those of European ancestry that affect adult lung function, as measured by forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) ratio. 23 of these SNPs have directionally consistent effects on both FEV1 and FEV1/FVC in children and adults [4].
European Respiratory Society