[HTML][HTML] Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
During differentiation of naive CD4+ helper T (TH) cells into effector cells, specific cytokine
gene loci undergo extensive changes in chromatin modification. A novel lineage of TH cells
that is regulated by transforming growth factor-β (TGFβ) and interleukin-6 (IL-6) has been
identified recently as promoting tissue inflammation. These inflammatory TH (THi) cells, also
called TH17 or TH IL-17, produce IL-17 and IL-17F, two highly homologous cytokines that
have genes located in the same chromosomal region. Here, using chromatin …
gene loci undergo extensive changes in chromatin modification. A novel lineage of TH cells
that is regulated by transforming growth factor-β (TGFβ) and interleukin-6 (IL-6) has been
identified recently as promoting tissue inflammation. These inflammatory TH (THi) cells, also
called TH17 or TH IL-17, produce IL-17 and IL-17F, two highly homologous cytokines that
have genes located in the same chromosomal region. Here, using chromatin …