Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
MJW Hanssen, J Hoeks, B Brans, AAJJ Van Der Lans… - Nature medicine, 2015 - nature.com
MJW Hanssen, J Hoeks, B Brans, AAJJ Van Der Lans, G Schaart, JJ Van Den Driessche…
Nature medicine, 2015•nature.comCold exposure may be a potential therapy for diabetes by increasing brown adipose tissue
(BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15° C) increased
peripheral insulin sensitivity by∼ 43% in eight type 2 diabetes subjects. Basal skeletal
muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-
activated protein kinase (AMPK) activation and only a minor increase in BAT glucose
uptake.
(BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15° C) increased
peripheral insulin sensitivity by∼ 43% in eight type 2 diabetes subjects. Basal skeletal
muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-
activated protein kinase (AMPK) activation and only a minor increase in BAT glucose
uptake.
Abstract
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
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