[PDF][PDF] Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

IW Asterholm, DI Mundy, J Weng, RGW Anderson… - Cell metabolism, 2012 - cell.com
IW Asterholm, DI Mundy, J Weng, RGW Anderson, PE Scherer
Cell metabolism, 2012cell.com
Caveolin-1 is a major structural component of raft structures within the plasma membrane
and has been implicated as a regulator of cellular signal transduction with prominent
expression in adipocytes. Here, we embarked on a comprehensive characterization of the
metabolic pathways dysregulated in caveolin-1 null mice. We found that these mice display
decreased circulating levels of total and high molecular weight adiponectin and a reduced
ability to change substrate use in response to feeding/fasting conditions. Caveolin-1 null …
Summary
Caveolin-1 is a major structural component of raft structures within the plasma membrane and has been implicated as a regulator of cellular signal transduction with prominent expression in adipocytes. Here, we embarked on a comprehensive characterization of the metabolic pathways dysregulated in caveolin-1 null mice. We found that these mice display decreased circulating levels of total and high molecular weight adiponectin and a reduced ability to change substrate use in response to feeding/fasting conditions. Caveolin-1 null mice are extremely lean but retain muscle mass despite lipodystrophy and massive metabolic dysfunction. Hepatic gluconeogenesis is chronically elevated, while hepatic steatosis is reduced. Our data suggest that the complex phenotype of the caveolin-1 null mouse is caused by altered metabolic and mitochondrial function in adipose tissue with a subsequent compensatory response driven mostly by the liver. This mouse model highlights the central contributions of adipose tissue for system-wide preservation of metabolic flexibility.
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