Inherited mutations in women with ovarian carcinoma
Importance Germline mutations inBRCA1andBRCA2are relatively common in women with
ovarian, fallopian tube, and peritoneal carcinoma (OC) causing a greatly increased lifetime
risk of these cancers, but the frequency and relevance of inherited mutations in other genes
is less well characterized. Objective To determine the frequency and importance of germline
mutations in cancer-associated genes in OC. Design, Setting, and Participants A study
population of 1915 woman with OC and available germline DNA were identified from the …
ovarian, fallopian tube, and peritoneal carcinoma (OC) causing a greatly increased lifetime
risk of these cancers, but the frequency and relevance of inherited mutations in other genes
is less well characterized. Objective To determine the frequency and importance of germline
mutations in cancer-associated genes in OC. Design, Setting, and Participants A study
population of 1915 woman with OC and available germline DNA were identified from the …