[HTML][HTML] Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer
Journal of clinical oncology, 2015•ncbi.nlm.nih.gov
Purpose Recent advances in DNA sequencing have led to the development of breast cancer
susceptibility gene panels for germline genetic testing of patients. We assessed the
frequency of mutations in 17 predisposition genes, including BRCA1 and BRCA2, in a large
cohort of patients with triple-negative breast cancer (TNBC) unselected for family history of
breast or ovarian cancer to determine the utility of germline genetic testing for those with
TNBC.
susceptibility gene panels for germline genetic testing of patients. We assessed the
frequency of mutations in 17 predisposition genes, including BRCA1 and BRCA2, in a large
cohort of patients with triple-negative breast cancer (TNBC) unselected for family history of
breast or ovarian cancer to determine the utility of germline genetic testing for those with
TNBC.
Abstract
Purpose
Recent advances in DNA sequencing have led to the development of breast cancer susceptibility gene panels for germline genetic testing of patients. We assessed the frequency of mutations in 17 predisposition genes, including BRCA1 and BRCA2, in a large cohort of patients with triple-negative breast cancer (TNBC) unselected for family history of breast or ovarian cancer to determine the utility of germline genetic testing for those with TNBC.
ncbi.nlm.nih.gov
