[PDF][PDF] Revised recommendations of the international working group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards …

BD Cheson, JM Bennett, KJ Kopecky… - Journal of clinical …, 2003 - Citeseer
BD Cheson, JM Bennett, KJ Kopecky, T Büchner, CL Willman, EH Estey, CA Schiffer…
Journal of clinical oncology, 2003Citeseer
An International Working Group met to revise the diagnostic and response criteria for acute
myelogenous leukemia originally published in 1990, as well as to provide definitions of
outcomes and reporting standards to improve interpretability of data and comparisons
among trials. Since the original publication, there have been major advances in our
understanding of the biology and molecular genetics of acute leukemia that are clinically
relevant and warrant incorporation into response definitions. Differences from the 1990 …
Abstract
An International Working Group met to revise the diagnostic and response criteria for acute myelogenous leukemia originally published in 1990, as well as to provide definitions of outcomes and reporting standards to improve interpretability of data and comparisons among trials. Since the original publication, there have been major advances in our understanding of the biology and molecular genetics of acute leukemia that are clinically relevant and warrant incorporation into response definitions. Differences from the 1990 recommendations included a category of leukemiafree state, new criteria for complete remission, including cytogenetic and molecular remissions and remission duration. Storage of viable blasts for correlative studies is important for future progress in the therapy of these disorders.
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