When the good go bad: mutant NPM1 in acute myeloid leukemia

P Kunchala, S Kuravi, R Jensen, J McGuirk, R Balusu - Blood reviews, 2018 - Elsevier
Abstract Nucleophosmin 1 (NPM1) is a nucleolar phosphoprotein that performs diverse
biological functions including molecular chaperoning, ribosome biogenesis, DNA repair,
and genome stability. Acute myeloid leukemia (AML) is a heterogeneous disease, more than
half of the AML cases exhibit normal karyotype (NK). Approximately 50–60 percent of
patients with NK-AML carry NPM1 mutations which are characterized by cytoplasmic
dislocation of the NPM1 protein. In AML, mutant NPM1 (NPM1c+) acts in a dominant …