Fc‐receptors as regulators of immunity

F Nimmerjahn, JV Ravetch - Advances in immunology, 2007 - Elsevier
Receptors for immunoglobulins [Fc‐receptors (FcRs)] are widely expressed throughout the
immune system. By binding to the antibody Fc‐portion, they provide a link between the
specificity of the adaptive immune system and the powerful effector functions triggered by
innate immune effector cells. By virtue of coexpression of activating and inhibitory FcRs on
the same cell, they set a threshold for immune cell activation by immune complexes (ICs).
Besides their involvement in the efferent phase of an immune response, they are also …