[HTML][HTML] Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility
MW Zimmerman, KE McQueeney, JS Isenberg… - Journal of Biological …, 2014 - ASBMB
Protein-tyrosine phosphatase 4A3 (PTP4A3) is highly expressed in multiple human cancers
and is hypothesized to have a critical, albeit poorly defined, role in the formation of
experimental tumors in mice. PTP4A3 is broadly expressed in many tissues so the cellular
basis of its etiological contributions to carcinogenesis may involve both tumor and stromal
cells. In particular, PTP4A3 is expressed in the tumor vasculature and has been proposed to
be a direct target of vascular endothelial growth factor (VEGF) signaling in endothelial cells …
and is hypothesized to have a critical, albeit poorly defined, role in the formation of
experimental tumors in mice. PTP4A3 is broadly expressed in many tissues so the cellular
basis of its etiological contributions to carcinogenesis may involve both tumor and stromal
cells. In particular, PTP4A3 is expressed in the tumor vasculature and has been proposed to
be a direct target of vascular endothelial growth factor (VEGF) signaling in endothelial cells …