[HTML][HTML] Alternative activation of STAT1 and STAT3 in response to interferon-γ
Y Qing, GR Stark - Journal of Biological Chemistry, 2004 - ASBMB
Interferon-γ (IFNγ) is a pluripotent cytokine whose major biological effects are mediated
through a pathway in which STAT1 is the predominant and essential transcription factor.
STAT3 can also be activated weakly by IFNγ, but the mechanism of activation and function of
STAT3 as a part of the interferon response are not known. Here we show that STAT3
activation is much stronger and more prolonged in STAT1-null mouse embryo fibroblasts
than in wild-type cells. In response to IFNγ, SRC-family kinases are required to activate …
through a pathway in which STAT1 is the predominant and essential transcription factor.
STAT3 can also be activated weakly by IFNγ, but the mechanism of activation and function of
STAT3 as a part of the interferon response are not known. Here we show that STAT3
activation is much stronger and more prolonged in STAT1-null mouse embryo fibroblasts
than in wild-type cells. In response to IFNγ, SRC-family kinases are required to activate …