Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: time course and the association with clinical status

S Yamanouchi, D Kudo, M Yamada, N Miyagawa… - Journal of critical …, 2013 - Elsevier
Purpose This study aimed to investigate the serial changes in plasma levels of mitochondrial
DNA (mtDNA) in patients with trauma and severe sepsis and the mechanism of increase in
mtDNA levels and the association between the levels and severity. Materials and Methods
We conducted a prospective observational study of patients with trauma having injuries with
an Abbreviated Injury Scale score of 3 or higher (n= 37) and patients with severe sepsis (n=
23). The mtDNA concentrations in clarified plasma were measured using real-time …