[PDF][PDF] Cardiolipin and the Nlrp3 inflammasome
LAJ O'Neill - Cell metabolism, 2013 - cell.com
Cell metabolism, 2013•cell.com
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and
colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between
cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that,
upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting
inflammation.
colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between
cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that,
upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting
inflammation.
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting inflammation.
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