Lupus neutrophils:'NET'gain in understanding lupus pathogenesis
NETs are a potent stimulus for IFNα release by plasmacytoid dendritic cells, and, as such,
may play an important role in propagation of the lupus phenotype. NETs can also directly
damage tissues–including the endothelium–with implications for lupus nephritis and
accelerated atherosclerosis. Whether aberrant NETosis is sufficient to trigger systemic lupus
erythematosus, and whether inhibition of NETosis can ameliorate clinical manifestations of
lupus, are open questions, and will be exciting topics of future research.
may play an important role in propagation of the lupus phenotype. NETs can also directly
damage tissues–including the endothelium–with implications for lupus nephritis and
accelerated atherosclerosis. Whether aberrant NETosis is sufficient to trigger systemic lupus
erythematosus, and whether inhibition of NETosis can ameliorate clinical manifestations of
lupus, are open questions, and will be exciting topics of future research.
Summary
NETs are a potent stimulus for IFNα release by plasmacytoid dendritic cells, and, as such, may play an important role in propagation of the lupus phenotype. NETs can also directly damage tissues–including the endothelium–with implications for lupus nephritis and accelerated atherosclerosis. Whether aberrant NETosis is sufficient to trigger systemic lupus erythematosus, and whether inhibition of NETosis can ameliorate clinical manifestations of lupus, are open questions, and will be exciting topics of future research.
Lippincott Williams & Wilkins