Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.
WW Cruikshank, DM Center, N Nisar… - Proceedings of the …, 1994 - National Acad Sciences
WW Cruikshank, DM Center, N Nisar, M Wu, B Natke, AC Theodore, H Kornfeld
Proceedings of the National Academy of Sciences, 1994•National Acad SciencesLymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a
migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its
chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2
receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a
novel interleukin with no significant homology to any previously described cytokine families.
There is an absolute requirement for both autoaggregation of LCF monomers and for …
migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its
chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2
receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a
novel interleukin with no significant homology to any previously described cytokine families.
There is an absolute requirement for both autoaggregation of LCF monomers and for …
Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a novel interleukin with no significant homology to any previously described cytokine families. There is an absolute requirement for both autoaggregation of LCF monomers and for membrane-expressed CD4 molecules for LCF-induced migration in lymphocytes.
National Acad Sciences