Mucins in cancer: protection and control of the cell surface
MA Hollingsworth, BJ Swanson - Nature Reviews Cancer, 2004 - nature.com
MA Hollingsworth, BJ Swanson
Nature Reviews Cancer, 2004•nature.comMucins—large extracellular proteins that are heavily glycosylated with complex
oligosaccharides—establish a selective molecular barrier at the epithelial surface and
engage in morphogenetic signal transduction. Alterations in mucin expression or
glycosylation accompany the development of cancer and influence cellular growth,
differentiation, transformation, adhesion, invasion and immune surveillance. Mucins are
used as diagnostic markers in cancer, and are under investigation as therapeutic targets for …
oligosaccharides—establish a selective molecular barrier at the epithelial surface and
engage in morphogenetic signal transduction. Alterations in mucin expression or
glycosylation accompany the development of cancer and influence cellular growth,
differentiation, transformation, adhesion, invasion and immune surveillance. Mucins are
used as diagnostic markers in cancer, and are under investigation as therapeutic targets for …
Abstract
Mucins — large extracellular proteins that are heavily glycosylated with complex oligosaccharides — establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction. Alterations in mucin expression or glycosylation accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance. Mucins are used as diagnostic markers in cancer, and are under investigation as therapeutic targets for cancer.
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