Transformation of ALK rearrangement-positive adenocarcinoma to small-cell lung cancer in association with acquired resistance to alectinib

N Takegawa, H Hayashi, N Iizuka… - Annals of …, 2016 - annalsofoncology.org
In their recent letter to the editor, Rodriguez-Wallberg et al.[1], incorrectly cite the study by
Demeestere et al.[2] as showing that gonadotropin-releasing hormone agonist (GnRHa)
cotreatment during chemotherapy was ineffective. As a matter of fact, Demeestere et al.[2],
who initially did not find a difference in the rate of premature ovarian failure [POF] after 1
year, have presented the 2-year follow-up of their patients [2, 3] claiming:'… the number of
patients who totally restored their ovarian function was significantly higher in the GnRHa …